Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Identifieur interne : 000930 ( Main/Exploration ); précédent : 000929; suivant : 000931Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Auteurs : Justin J. L. Wong [Australie] ; Dadi Gao [Australie] ; Trung V. Nguyen [Australie] ; Chau-To Kwok [Australie] ; Michelle Van Geldermalsen [Australie] ; Rob Middleton [Australie] ; Natalia Pinello [Australie] ; Annora Thoeng [Australie] ; Rajini Nagarajah [Australie] ; Jeff Holst [Australie] ; William Ritchie [Australie, France] ; John E. J. Rasko [Australie]Source :
- Nature Communications [ 2041-1723 ] ; 2017.
Abstract
While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA methylation at these sites. Accordingly, MeCP2 depletion in tissues and cells enhances IR. By analysing the MeCP2 interactome using mass spectrometry and RNA co-precipitation, we demonstrate that decreased MeCP2 binding near splice junctions facilitates IR via reduced recruitment of splicing factors, including Tra2b, and increased RNA polymerase II stalling. These results suggest an association between IR and a slower rate of transcription elongation, which reflects inefficient splicing factor recruitment. In summary, our results reinforce the interdependency between alternative splicing involving IR and epigenetic controls of gene expression.
Url:
DOI: 10.1038/ncomms15134
PubMed: 28480880
PubMed Central: 5424149
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000790
- to stream Pmc, to step Curation: 000789
- to stream Pmc, to step Checkpoint: 000230
- to stream PubMed, to step Corpus: 000C08
- to stream PubMed, to step Curation: 000C05
- to stream PubMed, to step Checkpoint: 000C05
- to stream Ncbi, to step Merge: 004773
- to stream Ncbi, to step Curation: 004773
- to stream Ncbi, to step Checkpoint: 004773
- to stream Main, to step Merge: 000925
- to stream Main, to step Curation: 000930
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment</title><author><name sortKey="Wong, Justin J L" sort="Wong, Justin J L" uniqKey="Wong J" first="Justin J. L." last="Wong">Justin J. L. Wong</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Dadi" sort="Gao, Dadi" uniqKey="Gao D" first="Dadi" last="Gao">Dadi Gao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V." last="Nguyen">Trung V. Nguyen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kwok, Chau To" sort="Kwok, Chau To" uniqKey="Kwok C" first="Chau-To" last="Kwok">Chau-To Kwok</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Geldermalsen, Michelle" sort="Van Geldermalsen, Michelle" uniqKey="Van Geldermalsen M" first="Michelle" last="Van Geldermalsen">Michelle Van Geldermalsen</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Origins of Cancer Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Middleton, Rob" sort="Middleton, Rob" uniqKey="Middleton R" first="Rob" last="Middleton">Rob Middleton</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pinello, Natalia" sort="Pinello, Natalia" uniqKey="Pinello N" first="Natalia" last="Pinello">Natalia Pinello</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nagarajah, Rajini" sort="Nagarajah, Rajini" uniqKey="Nagarajah R" first="Rajini" last="Nagarajah">Rajini Nagarajah</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Origins of Cancer Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>CNRS, UMR 5203</institution>, 34094 Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Cell and Molecular Therapies, Royal Prince Alfred Hospital</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28480880</idno><idno type="pmc">5424149</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424149</idno><idno type="RBID">PMC:5424149</idno><idno type="doi">10.1038/ncomms15134</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000790</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000790</idno><idno type="wicri:Area/Pmc/Curation">000789</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000789</idno><idno type="wicri:Area/Pmc/Checkpoint">000230</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000230</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000C08</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C08</idno><idno type="wicri:Area/PubMed/Curation">000C05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C05</idno><idno type="wicri:Area/PubMed/Checkpoint">000C05</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C05</idno><idno type="wicri:Area/Ncbi/Merge">004773</idno><idno type="wicri:Area/Ncbi/Curation">004773</idno><idno type="wicri:Area/Ncbi/Checkpoint">004773</idno><idno type="wicri:Area/Main/Merge">000925</idno><idno type="wicri:Area/Main/Curation">000930</idno><idno type="wicri:Area/Main/Exploration">000930</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment</title><author><name sortKey="Wong, Justin J L" sort="Wong, Justin J L" uniqKey="Wong J" first="Justin J. L." last="Wong">Justin J. L. Wong</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Dadi" sort="Gao, Dadi" uniqKey="Gao D" first="Dadi" last="Gao">Dadi Gao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V." last="Nguyen">Trung V. Nguyen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kwok, Chau To" sort="Kwok, Chau To" uniqKey="Kwok C" first="Chau-To" last="Kwok">Chau-To Kwok</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Geldermalsen, Michelle" sort="Van Geldermalsen, Michelle" uniqKey="Van Geldermalsen M" first="Michelle" last="Van Geldermalsen">Michelle Van Geldermalsen</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Origins of Cancer Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Middleton, Rob" sort="Middleton, Rob" uniqKey="Middleton R" first="Rob" last="Middleton">Rob Middleton</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pinello, Natalia" sort="Pinello, Natalia" uniqKey="Pinello N" first="Natalia" last="Pinello">Natalia Pinello</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nagarajah, Rajini" sort="Nagarajah, Rajini" uniqKey="Nagarajah R" first="Rajini" last="Nagarajah">Rajini Nagarajah</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Origins of Cancer Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>CNRS, UMR 5203</institution>, 34094 Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>, Sydney, New South Wales 2006,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Cell and Molecular Therapies, Royal Prince Alfred Hospital</institution>, Camperdown, New South Wales 2050,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA methylation at these sites. Accordingly, MeCP2 depletion in tissues and cells enhances IR. By analysing the MeCP2 interactome using mass spectrometry and RNA co-precipitation, we demonstrate that decreased MeCP2 binding near splice junctions facilitates IR via reduced recruitment of splicing factors, including Tra2b, and increased RNA polymerase II stalling. These results suggest an association between IR and a slower rate of transcription elongation, which reflects inefficient splicing factor recruitment. In summary, our results reinforce the interdependency between alternative splicing involving IR and epigenetic controls of gene expression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yap, K" uniqKey="Yap K">K. Yap</name></author><author><name sortKey="Lim, Z Q" uniqKey="Lim Z">Z. Q. Lim</name></author><author><name sortKey="Khandelia, P" uniqKey="Khandelia P">P. Khandelia</name></author><author><name sortKey="Friedman, B" uniqKey="Friedman B">B. Friedman</name></author><author><name sortKey="Makeyev, E V" uniqKey="Makeyev E">E. V. Makeyev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong J J L" uniqKey="Wong J J L">Wong J.J.-L.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, M J" uniqKey="Moore M">M. J. Moore</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Kennedy, C J" uniqKey="Kennedy C">C. J. Kennedy</name></author><author><name sortKey="Silver, P A" uniqKey="Silver P">P. A. Silver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ergun, A" uniqKey="Ergun A">A. Ergun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaked, I" uniqKey="Shaked I">I. Shaked</name></author><author><name sortKey="Zimmerman, G" uniqKey="Zimmerman G">G. Zimmerman</name></author><author><name sortKey="Soreq, H" uniqKey="Soreq H">H. Soreq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padgett, R A" uniqKey="Padgett R">R. A. Padgett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, C" uniqKey="Edwards C">C. Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pimentel, H" uniqKey="Pimentel H">H. Pimentel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braunschweig, U" uniqKey="Braunschweig U">U. Braunschweig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, R" uniqKey="Guo R">R. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De La Mata, M" uniqKey="De La Mata M">M. de la Mata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maunakea, A K" uniqKey="Maunakea A">A. K. Maunakea</name></author><author><name sortKey="Chepelev, I" uniqKey="Chepelev I">I. Chepelev</name></author><author><name sortKey="Cui, K" uniqKey="Cui K">K. Cui</name></author><author><name sortKey="Zhao, K" uniqKey="Zhao K">K. Zhao</name></author><author><name sortKey="Intragenic, D N A" uniqKey="Intragenic D">D. N. A. Intragenic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shukla, S" uniqKey="Shukla S">S. Shukla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gascard, P" uniqKey="Gascard P">P. Gascard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name></author><author><name sortKey="Coutinho Mansfield, G" uniqKey="Coutinho Mansfield G">G. Coutinho-Mansfield</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Pandit, S" uniqKey="Pandit S">S. Pandit</name></author><author><name sortKey="Fu, X D" uniqKey="Fu X">X.-D. Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fong, Y W" uniqKey="Fong Y">Y. W. Fong</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lev Maor, G" uniqKey="Lev Maor G">G. Lev Maor</name></author><author><name sortKey="Yearim, A" uniqKey="Yearim A">A. Yearim</name></author><author><name sortKey="Ast, G" uniqKey="Ast G">G. Ast</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yearim, A" uniqKey="Yearim A">A. Yearim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olins, A L" uniqKey="Olins A">A. L. Olins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porfiri, E" uniqKey="Porfiri E">E. Porfiri</name></author><author><name sortKey="Hoffbrand, A" uniqKey="Hoffbrand A">A. Hoffbrand</name></author><author><name sortKey="Wickremasinghe, R" uniqKey="Wickremasinghe R">R. Wickremasinghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lodhi, I J" uniqKey="Lodhi I">I. J. Lodhi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crawford, L J A" uniqKey="Crawford L">L. J. A. Crawford</name></author><author><name sortKey="Peake, R" uniqKey="Peake R">R. Peake</name></author><author><name sortKey="Price, S" uniqKey="Price S">S. Price</name></author><author><name sortKey="Morris, T C M" uniqKey="Morris T">T. C. M. Morris</name></author><author><name sortKey="Irvine, A E" uniqKey="Irvine A">A. E. Irvine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, P A" uniqKey="Jones P">P. A. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li Byarlay, H" uniqKey="Li Byarlay H">H. Li-Byarlay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laurent, L" uniqKey="Laurent L">L. Laurent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gombart, A F" uniqKey="Gombart A">A. F. Gombart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nacken, W" uniqKey="Nacken W">W. Nacken</name></author><author><name sortKey="Roth, J" uniqKey="Roth J">J. Roth</name></author><author><name sortKey="Sorg, C" uniqKey="Sorg C">C. Sorg</name></author><author><name sortKey="Kerkhoff, C" uniqKey="Kerkhoff C">C. Kerkhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nathan, C" uniqKey="Nathan C">C. Nathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, K T" uniqKey="Chan K">K. T. Chan</name></author><author><name sortKey="Creed, S J" uniqKey="Creed S">S. J. Creed</name></author><author><name sortKey="Bear, J E" uniqKey="Bear J">J. E. Bear</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salerno, D M" uniqKey="Salerno D">D. M. Salerno</name></author><author><name sortKey="Tront, J S" uniqKey="Tront J">J. S. Tront</name></author><author><name sortKey="Hoffman, B" uniqKey="Hoffman B">B. Hoffman</name></author><author><name sortKey="Liebermann, D A" uniqKey="Liebermann D">D. A. Liebermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gombart, A F" uniqKey="Gombart A">A. F. Gombart</name></author><author><name sortKey="Grewal, J" uniqKey="Grewal J">J. Grewal</name></author><author><name sortKey="Koeffler, H P" uniqKey="Koeffler H">H. P. Koeffler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baubec, T" uniqKey="Baubec T">T. Baubec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baubec, T" uniqKey="Baubec T">T. Baubec</name></author><author><name sortKey="Ivanek, R" uniqKey="Ivanek R">R. Ivánek</name></author><author><name sortKey="Lienert, F" uniqKey="Lienert F">F. Lienert</name></author><author><name sortKey="Schubeler, D" uniqKey="Schubeler D">D. Schübeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, J I" uniqKey="Young J">J. I. Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maxwell, S S" uniqKey="Maxwell S">S. S. Maxwell</name></author><author><name sortKey="Pelka, G J" uniqKey="Pelka G">G. J. Pelka</name></author><author><name sortKey="Tam, P P L" uniqKey="Tam P">P. P. L. Tam</name></author><author><name sortKey="El Osta, A" uniqKey="El Osta A">A. El-Osta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, S W" uniqKey="Long S">S. W. Long</name></author><author><name sortKey="Ooi, J Y Y" uniqKey="Ooi J">J. Y. Y. Ooi</name></author><author><name sortKey="Yau, P M" uniqKey="Yau P">P. M. Yau</name></author><author><name sortKey="Jones, P L" uniqKey="Jones P">P. L. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, R P" uniqKey="Ghosh R">R. P. Ghosh</name></author><author><name sortKey="Horowitz Scherer, R A" uniqKey="Horowitz Scherer R">R. A. Horowitz-Scherer</name></author><author><name sortKey="Nikitina, T" uniqKey="Nikitina T">T. Nikitina</name></author><author><name sortKey="Shlyakhtenko, L S" uniqKey="Shlyakhtenko L">L. S. Shlyakhtenko</name></author><author><name sortKey="Woodcock, C L" uniqKey="Woodcock C">C. L. Woodcock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shepard, P J" uniqKey="Shepard P">P. J. Shepard</name></author><author><name sortKey="Hertel, K J" uniqKey="Hertel K">K. J. Hertel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dichmann, D S" uniqKey="Dichmann D">D. S. Dichmann</name></author><author><name sortKey="Walentek, P" uniqKey="Walentek P">P. Walentek</name></author><author><name sortKey="Harland, R M" uniqKey="Harland R">R. M. Harland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Best, A" uniqKey="Best A">A. Best</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussein, S M I" uniqKey="Hussein S">S. M. I. Hussein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dvinge, H" uniqKey="Dvinge H">H. Dvinge</name></author><author><name sortKey="Bradley, R" uniqKey="Bradley R">R. Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, H" uniqKey="Jung H">H. Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ni, T" uniqKey="Ni T">T. Ni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, H" uniqKey="Wen H">H. Wen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marina, R J" uniqKey="Marina R">R. J. Marina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tekpli, X" uniqKey="Tekpli X">X. Tekpli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, C X" uniqKey="Song C">C.-X. Song</name></author><author><name sortKey="Yi, C" uniqKey="Yi C">C. Yi</name></author><author><name sortKey="He, C" uniqKey="He C">C. He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buckstein, R" uniqKey="Buckstein R">R. Buckstein</name></author><author><name sortKey="Yee, K" uniqKey="Yee K">K. Yee</name></author><author><name sortKey="Wells, R A" uniqKey="Wells R">R. A. Wells</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, R" uniqKey="Brown R">R. Brown</name></author><author><name sortKey="Curry, E" uniqKey="Curry E">E. Curry</name></author><author><name sortKey="Magnani, L" uniqKey="Magnani L">L. Magnani</name></author><author><name sortKey="Wilhelm Benartzi, C S" uniqKey="Wilhelm Benartzi C">C. S. Wilhelm-Benartzi</name></author><author><name sortKey="Borley, J" uniqKey="Borley J">J. Borley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Middleton, R" uniqKey="Middleton R">R. Middleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, J" uniqKey="Wong J">J. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammed, H" uniqKey="Mohammed H">H. Mohammed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Challen, G A" uniqKey="Challen G">G. A. Challen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, M" uniqKey="Jeong M">M. Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lund, K" uniqKey="Lund K">K. Lund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trapnell, C" uniqKey="Trapnell C">C. Trapnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dobin, A" uniqKey="Dobin A">A. Dobin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Audic, S" uniqKey="Audic S">S. Audic</name></author><author><name sortKey="Claverie, J M" uniqKey="Claverie J">J. M. Claverie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, D W" uniqKey="Huang D">D. W. Huang</name></author><author><name sortKey="Sherman, B T" uniqKey="Sherman B">B. T. Sherman</name></author><author><name sortKey="Lempicki, R A" uniqKey="Lempicki R">R. A. Lempicki</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Wong, Justin J L" sort="Wong, Justin J L" uniqKey="Wong J" first="Justin J. L." last="Wong">Justin J. L. Wong</name></noRegion><name sortKey="Gao, Dadi" sort="Gao, Dadi" uniqKey="Gao D" first="Dadi" last="Gao">Dadi Gao</name><name sortKey="Gao, Dadi" sort="Gao, Dadi" uniqKey="Gao D" first="Dadi" last="Gao">Dadi Gao</name><name sortKey="Gao, Dadi" sort="Gao, Dadi" uniqKey="Gao D" first="Dadi" last="Gao">Dadi Gao</name><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name><name sortKey="Kwok, Chau To" sort="Kwok, Chau To" uniqKey="Kwok C" first="Chau-To" last="Kwok">Chau-To Kwok</name><name sortKey="Kwok, Chau To" sort="Kwok, Chau To" uniqKey="Kwok C" first="Chau-To" last="Kwok">Chau-To Kwok</name><name sortKey="Kwok, Chau To" sort="Kwok, Chau To" uniqKey="Kwok C" first="Chau-To" last="Kwok">Chau-To Kwok</name><name sortKey="Middleton, Rob" sort="Middleton, Rob" uniqKey="Middleton R" first="Rob" last="Middleton">Rob Middleton</name><name sortKey="Middleton, Rob" sort="Middleton, Rob" uniqKey="Middleton R" first="Rob" last="Middleton">Rob Middleton</name><name sortKey="Nagarajah, Rajini" sort="Nagarajah, Rajini" uniqKey="Nagarajah R" first="Rajini" last="Nagarajah">Rajini Nagarajah</name><name sortKey="Nagarajah, Rajini" sort="Nagarajah, Rajini" uniqKey="Nagarajah R" first="Rajini" last="Nagarajah">Rajini Nagarajah</name><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V." last="Nguyen">Trung V. Nguyen</name><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V." last="Nguyen">Trung V. Nguyen</name><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V." last="Nguyen">Trung V. Nguyen</name><name sortKey="Pinello, Natalia" sort="Pinello, Natalia" uniqKey="Pinello N" first="Natalia" last="Pinello">Natalia Pinello</name><name sortKey="Pinello, Natalia" sort="Pinello, Natalia" uniqKey="Pinello N" first="Natalia" last="Pinello">Natalia Pinello</name><name sortKey="Pinello, Natalia" sort="Pinello, Natalia" uniqKey="Pinello N" first="Natalia" last="Pinello">Natalia Pinello</name><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name><name sortKey="Van Geldermalsen, Michelle" sort="Van Geldermalsen, Michelle" uniqKey="Van Geldermalsen M" first="Michelle" last="Van Geldermalsen">Michelle Van Geldermalsen</name><name sortKey="Van Geldermalsen, Michelle" sort="Van Geldermalsen, Michelle" uniqKey="Van Geldermalsen M" first="Michelle" last="Van Geldermalsen">Michelle Van Geldermalsen</name><name sortKey="Wong, Justin J L" sort="Wong, Justin J L" uniqKey="Wong J" first="Justin J. L." last="Wong">Justin J. L. Wong</name><name sortKey="Wong, Justin J L" sort="Wong, Justin J L" uniqKey="Wong J" first="Justin J. L." last="Wong">Justin J. L. Wong</name></country><country name="France"><noRegion><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000930 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000930 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5424149
|texte= Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28480880" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |